Arsene Wenger must consider whether to risk Alexis Sanchez against Manchester United ahead of a crucial period for in the Premier League and the Champions League.
“I completely understand that Alexis wanted to play in qualifiers,” he said.
“They are not friendlies. Chile are not in a fantastic position to qualify for the World Cup and I understand that Alexis is keen to play for his country in such an important game.
“In the Premier League, the first decisive games are also coming up, so you have to pay a price. We lost important players in November for long periods last year.”
Arsenal have not won at Old Trafford in the Premier League for 10 years but they will go top of the table by winning the lunchtime kick-off.
Wenger added: “We had an opportunity to go top of the League against Tottenham that we did not take and we want to respond straight away with the positive result this weekend.”
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